透明质酸(HA)被广泛地用于生物医药领域.以1-乙基-3-(3-二甲基氨丙基)-碳化二亚胺/N-羟基丁二酰亚胺(EDC/NHS)催化HA与己二酸二酰肼(ADH)反应,制备化学交联的HA水凝胶.通过扫描电镜和红外光谱来测定HA与HA水凝胶的结构,测量HA水凝胶在模拟胃肠液中的溶胀率,并以牛血清白蛋白(BSA)为模型药物,初步探讨了HA水凝胶体系的释药行为.实验结果显示:HA水凝胶由酰胺键生成三维网络结构且网络孔径较大,具有较好的吸水性能.该水凝胶制备过程简单,反应迅速,条件温和,属酸敏突释释药体系.
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